Computational Prediction of Functional Modules and Their Regulatory Networks in Microbial Organisms

by

Ying Xu
Department of Biochemistry and Molecular Biology
University of Georgia

Friday, May 9, 2008
11:00 a.m. Seminar
12:00 p.m. Lunch
402 Walter Library

In this talk, I will present our recent work on computational prediction of biological networks in microbial organisms. I will discuss a number of computational techniques that we have been developing in the past few years, including prediction of genomic structures such as operons/regulons, prediction of cis regulatory elements and protein-DNA interactions, prediction of functional modules, and mapping of pathways/networks across microbial genomes, in support of our network prediction work. I will also discuss the challenging issues we are facing in terms of developing more effective computational tools and getting experimental data. I will then demonstrate how these tools have been used to elucidate a number of networks in cyanobacteria, including phosphorous assimilation network, carbon fixation network and nitrogen assimilation network and its crosstalk network with photosynthesis.

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